Summary of pharmacokinetic parameters obtained in rats after administration (by mouth) of BBR and 6-F-BBRa
| Parameter | BBR | 6-F-BBR |
|---|---|---|
| Cmax (μg/ml) | 26.80 ± 11.19 | 54.59 ± 10.17b |
| Tmax (h) | 1.25 ± 0.27 | 1.75 ± 0.27c |
| AUC(0-t) (μg/ml·h) | 121.62 ± 39.20 | 245.35 ± 28.80d |
| AUC(0-∞) (μg/ml·h) | 123.66 ± 38.41 | 256.20 ± 43.88d |
| CL/F (l/h/kg) | 0.09 ± 0.03 | 0.04 ± 0.01b |
| t1/2 (h) | 3.86 ± 1.27 | 2.59 ± 0.55 |
| Vz/F (l/kg) | 0.52 ± 0.28 | 0.15 ± 0.02c |
AUC, area under the curve; Tmax, time required to reach maximum concentration; CL/F, clearance rate; Vz/F, apparent volume of distribution.
↵a 10 mg/kg, n = 6.
↵b Significantly different from BBR-treated mice (P < 0.01).
↵c Significantly different from BBR-treated mice (P < 0.05).
↵d Significantly different from BBR-treated mice (P < 0.001).