Relationship between the presence of a predicted heme covalent link and 20-HETE formation in human CYP4 enzymes
| Subfamily | Enzyme | Localization | Covalent Heme | AA Metabolite |
|---|---|---|---|---|
| CYP4A | 4A11 | Liver, kidney | Yes (FEGHDT) | 20-HETE Powell et al. (1998) |
| 4A22 | Liver, kidney | Yes (FEGHDT) | — | |
| CYP4FB | 4B1 | Lung, bladder | Yes (FEGHDT) | — |
| CYP4V | 4V2 | Retina | Yes (FEGHDT) | 20-HETE Nakano (2011) |
| CYP4F | 4F2 | Liver, kidney | Yes (FEGHDT) | 20-HETE Powell et al. (1998) |
| 4F3A | Myeloid tissues | Yes (FEGHDT) | 20-HETE Fer et al. (2008) | |
| 4F3B | Liver, kidney | Yes (FEGHDT) | 20-HETE Christmas et al. (2001) | |
| 4F11 | Liver, kidney | Yes (FEGHDT) | 20-HETE Tang et al. (2010) | |
| 4F22 | Skin | Yes (FEGHDT) | — | |
| 4F8 | Urogenital | No (FGGHDT) | 18-HETE Bylund et al. (2000) | |
| 4F12 | Liver, intestine | No (FGGHDT) | 18-HETE Bylund et al. (2001) | |
| CYP4X | 4X1 | Brain, skin | No (LAGHDT) | 14,15-EET Stark et al. (2008) |
| CYP4Z | 4Z1 | Breast tissue | No (FAGHDT) | 20-HETE Yu et al. (2012) |
| 4Z1 | Breast tissue | No (FAGHDT) | 14,15-EET (current study) |