Normalized sensitivity coefficients (elasticity indices) for selected parameters of M1 and M2 PBPK models
| M1 | M2 | |||
|---|---|---|---|---|
| Cmax | AUC | Cmax | AUC | |
| Plasma protein binding (fu) | 1.053 | 1.03 | 0.863 | 0.972 |
| Blood-to-plasma ratio (B/P) | 0.176 | 0.0003 | 0.801 | 0.007 |
| Log P | 1.097 | 0.002 | 0.412 | 0.214 |
| CLint (metabolite formation) | 0.731 | 0.592 | 0.603 | 0.595 |
| CLint (metabolism of metabolite) | 0.773 | 0.997 | 0.807 | 0.912 |