M1 | M2 | |||
---|---|---|---|---|
Cmax | AUC | Cmax | AUC | |
Plasma protein binding (fu) | 1.053 | 1.03 | 0.863 | 0.972 |
Blood-to-plasma ratio (B/P) | 0.176 | 0.0003 | 0.801 | 0.007 |
Log P | 1.097 | 0.002 | 0.412 | 0.214 |
CLint (metabolite formation) | 0.731 | 0.592 | 0.603 | 0.595 |
CLint (metabolism of metabolite) | 0.773 | 0.997 | 0.807 | 0.912 |