TABLE 1

Pharmacokinetic parameters of acetaminophen after oral administration in mice pretreated with or without probiotics (n = 6)

Parameters	Acetaminophen (10 mg/kg)
Parameters	Control	K8	K9
T_max (h)	0.16 ± 0.00	0.16 ± 0.00	0.16 ± 0.00
C_max (μg/ml)	4.72 ± 0.83	3.30 ± 0.57^*	3.96 ± 0.96
AUC (μg/h per milliliter)	3.51 ± 0.47	2.40 ± 0.26^**	3.65 ± 0.98
Cl/F (l/h per kilogram)	2.89 ± 0.39	4.14 ± 0.49^**	2.89 ± 0.71
t_1/2 (h)	1.09 ± 0.35	1.65 ± 0.70	1.22 ± 0.24

T_max, time taken to reach maximum. Data are presented as the mean ± S.D.
↵* P < 0.05 vs. control;
↵** P < 0.01 vs. control.