TABLE 3 

Blood and plasma PK summary of total [14C] radioactivity by liquid scintillation count and plasma PK of MMB and metabolites by LC-MS/MS following a single 200-mg dose in healthy subjects (n = 6, mean ± S.D.)

ParameterRadioactivity in Blood and PlasmaNonradiolabeled Analytes in Plasma
BloodPlasmaMMBM19M21
Cmax, ng/ml1507 ± 1451860 ± 213768 ± 17143.0 ± 9.81054 ± 375
AUC, h•ng/ml11,759 ± 292616,327 ± 30294049 ± 1380665 ± 2477234 ± 1122
Tmax, ha2.0 (2.0, 2.5)3.3 (2.5, 3.5)1.3 (1.0, 2.0)4.0 (4.0, 4.0)3.8 (2.5, 4.0)
t1/2, ha4.0 (3.9, 4.3)6.0 (5.9, 6.4)3.7 (3.3, 4.7)9.3 (7.0, 9.8)3.6 (3.2, 5.2)
CL/F, liters/h per kilogramNANA0.68 ± 0.19NANA
  • CL/F, clearance drug from plasma after oral administration; LC-MS/MS, liquid chromatography–tandem mass spectrometry; Tmax, time to Cmax.

  • a Data presented as median (quartile 1, 3).