TABLE 3

Enriched biologic processes after incubation of PHHs with CITCO

GO Number	Biologic Process	Count	P Value	Genes
Deregulated by CITCO in the absence of EGF only

GO.0042738	Exogenous drug catabolic process	6	1.09e−05	CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4
GO.0016098	Monoterpenoid metabolic process	4	4.66e−05	CYP1A2, CYP2C19, CYP2C9, CYP3A4
GO.0019373	Epoxygenase P450 pathway	5	0.000103	CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9
GO.0042221	Response to chemical	41	0.000103	ADCY2, AKR1B1, ANXA3, CA3, CPEB3, CREB3L3, CTGF, CXCL5, CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, EPHX1, ETV1, F2R, GSTA1, IL18, ITGA2, KCNA5, KRT19, MATN2, MICALL1, MRC1, MYL9, OR1C1, OR51B4, PANX1, PF4V1, POR, SERPINE1, SLC23A1, SOCS2, SOX2, TGFB2, TMEM67, TNFSF11, WNT6
GO.0050896	Response to stimulus	58	0.000166	ADCY2, AK7, AMOTL1, ANO1, BOC, CA3, CPE, CPEB3, CRIM1, CXCL5, CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, DKK3, DST, EPHX1, ETV1, F2R, GSTA1, HRH4, IL18, ITGA2, KCNA5, KRT19, LRRN4, MAP4K5, MATN2, MCTP2, MICALL1, MRC1, MYL9, NABP1, OR1C1, OR51B4, PF4V1, PLK2, PNMA1, POR, RASEF, RRAD, RRM1, SERPINE1, SLC23A1, SOCS2, STK17A, SUSD4, TACSTD2, TGFB2, TMEM67, TNC, TNFSF11, VSIG4, WNT6
GO.0097267	Omega hydroxylase P450 pathway	4	0.000166	CYP1A2, CYP2C19, CYP2C8, CYP2C9
GO.0006805	Xenobiotic metabolic process	9	0.000299	CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, GSTA1
GO.0071466	Cellular response to xenobiotic stimulus	9	0.00033	CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, GSTA1
GO.0070989	Oxidative demethylation	4	0.00102	CYP1A2, CYP2C8, CYP2C9, CYP3A4
GO.1901700	Response to oxygen-containing compound	20	0.00389	ADCY2, AKR1B1, CA3, CPEB3, CTGF, CXCL5, CYP1A2, F2R, IGFBP1, IL18, KCNA5, MRC1, PANX1, PAX2, PF4V1, POR, SERPINE1, SOCS2, TGFB2, WNT6
Deregulated by CITCO in the presence of EGF only

GO.0006397	mRNA processing	9	0.00486	DHX9, HNRNPC, MBNL2, RBM22, RBM27, SON, SRRM2, SYNCRIP, THRAP3
GO.0048255	mRNA stabilization	4	0.00486	DHX9, HNRNPC, SYNCRIP, THRAP3
GO.0016071	mRNA metabolic process	10	0.00533	DHX9, EIF4G1, HNRNPC, MBNL2, RBM22, RBM27, SON, SRRM2, SYNCRIP, THRAP3
GO.0008380	RNA splicing	8	0.0061	DHX9, HNRNPC, MBNL2, RBM22, SON, SRRM2, SYNCRIP, THRAP3

IGF, insulin-like growth factor.