Enriched biologic processes following incubation of PHHs with PB
| GO Number | Biologic Process | Count | P Value | Genes |
|---|---|---|---|---|
| Deregulated by PB only in medium without EGF | ||||
| GO.0008202 | Steroid metabolic process | 10 | 0.00081 | ABCG1, AKR1B1, AKR1B10, CYP1A2, DHCR24, HMGCS1, HSD17B2, NSDHL, SLC27A2, TM7SF2 |
| GO.0033993 | Response to lipid | 17 | 0.00081 | ABCG1, ANKRD1, ANXA3, BAX, CDO1, CTGF, CXCL5, CYP1A2, HMGCS1, HSD17B2, INHBA, KLF4, KRAS, KRT19, MRC1, PELI1, SOCS3 |
| GO.0006694 | Steroid biosynthetic process | 7 | 0.00273 | AKR1B1, DHCR24, HMGCS1, HSD17B2, NSDHL, SLC27A2, TM7SF2 |
| GO.0006629 | Lipid metabolic process | 18 | 0.0028 | ABCG1, AKR1B1, AKR1B10, ANKRD1, BAX, CAV1, CTGF, CYP1A2, CYP2A7, DHCR24, ELOVL6, FADS1, HSD17B2, ME1, NSDHL, PNPLA3, RDH16, TM7SF2 |
| GO.0044281 | Small molecule metabolic process | 26 | 0.0028 | ABCG1, AKR1B10, ANKRD1, CAV1, CTGF, CTPS1, CYP1A2, CYP2A7, DHCR24, ELOVL6, ENTPD5, FADS1, GCAT, GLYAT, GSTA1, GSTA3, HMGCS1, HOGA1, MAT1A, ME1, NSDHL, PNPLA3, SLC23A1, SLC25A15, TM7SF2, UGT1A6 |
| GO.0009725 | Response to hormone | 16 | 0.00289 | ABCG1, AKR1B1, ANXA3, BAX, CAV1, CDO1, CTGF, CYP1A2, DHCR24, HMGCS1, IGFBP1, INHBA, KRT19, ME1, STEAP2, UGT1A6 |
| GO.0042221 | Response to chemical | 35 | 0.00529 | ABCG1, AKR1B1, ANKRD1, ANXA3, CAV1, CCL16, CDO1, CPEB3, CTGF, CTPS1, CUX2, CXCL5, CYP1A2, CYP2A7, DHCR24, FSTL3, GLYAT, GSTA1, GSTA3, HMGCS1, HSD17B2, KLF4, KRT19, MAT1A, MATN2, ME1, MRC1, MT1M, MYL9, NTN4, PELI1, SLC23A1, SLC47A1, STEAP2, UGT1A6 |
| Deregulated by PB only in medium with EGF | ||||
| GO.0048255 | mRNA stabilization | 4 | 0.00728 | DHX9, HNRNPC, SYNCRIP, THRAP3 |
| Deregulated by PB in the presence and absence of EGF | ||||
| GO.0006805 | Xenobiotic metabolic process | 13 | 1.5e−13 | CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4A11, SULT2A1, UGT1A1, UGT1A8 |
| GO.0071466 | Cellular response to xenobiotic stimulus | 13 | 1.5e−13 | CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4A11, SULT2A1, UGT1A1, UGT1A8 |
| GO.0017144 | Drug metabolic process | 9 | 9.51e−13 | CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A5, UGT1A1, UGT1A8 |
| GO.0042737 | Drug catabolic process | 7 | 8.5e−11 | CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A5 |
| GO.0019373 | Epoxygenase P450 pathway | 6 | 4.24e−09 | CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP4A11 |
| GO.0042738 | Exogenous drug catabolic process | 6 | 7.24e−09 | CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4 |
| GO.0032787 | Monocarboxylic acid metabolic process | 13 | 9.67e−09 | AKR1D1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP4A11, FASN, PDK4, POR, SULT2A1, UGT1A1, UGT1A8 |
| GO.0044281 | Small molecule metabolic process | 22 | 1.24e−08 | ABCB1, AKR1D1, ALAS1, CYB5A, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4A11, DIO1, FASN, PDK4, POR, PRODH2, SULT2A1, UGT1A1, UGT1A8 |
| GO.0019752 | Carboxylic acid metabolic process | 15 | 2.28e−08 | AKR1D1, CYB5A, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP4A11, FASN, PDK4, POR, PRODH2, SULT2A1, UGT1A1, UGT1A8 |
| GO.0008202 | Steroid metabolic process | 10 | 4.36e−08 | AKR1D1, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP3A4, CYP3A5, SULT2A1, UGT1A1, UGT1A8 |