TABLE 4 

Enriched biologic processes following incubation of PHHs with PB

GO NumberBiologic ProcessCountP ValueGenes
Deregulated by PB only in medium without EGF
GO.0008202Steroid metabolic process100.00081ABCG1, AKR1B1, AKR1B10, CYP1A2, DHCR24, HMGCS1, HSD17B2, NSDHL, SLC27A2, TM7SF2
GO.0033993Response to lipid170.00081ABCG1, ANKRD1, ANXA3, BAX, CDO1, CTGF, CXCL5, CYP1A2, HMGCS1, HSD17B2, INHBA, KLF4, KRAS, KRT19, MRC1, PELI1, SOCS3
GO.0006694Steroid biosynthetic process70.00273AKR1B1, DHCR24, HMGCS1, HSD17B2, NSDHL, SLC27A2, TM7SF2
GO.0006629Lipid metabolic process180.0028ABCG1, AKR1B1, AKR1B10, ANKRD1, BAX, CAV1, CTGF, CYP1A2, CYP2A7, DHCR24, ELOVL6, FADS1, HSD17B2, ME1, NSDHL, PNPLA3, RDH16, TM7SF2
GO.0044281Small molecule metabolic process260.0028ABCG1, AKR1B10, ANKRD1, CAV1, CTGF, CTPS1, CYP1A2, CYP2A7, DHCR24, ELOVL6, ENTPD5, FADS1, GCAT, GLYAT, GSTA1, GSTA3, HMGCS1, HOGA1, MAT1A, ME1, NSDHL, PNPLA3, SLC23A1, SLC25A15, TM7SF2, UGT1A6
GO.0009725Response to hormone160.00289ABCG1, AKR1B1, ANXA3, BAX, CAV1, CDO1, CTGF, CYP1A2, DHCR24, HMGCS1, IGFBP1, INHBA, KRT19, ME1, STEAP2, UGT1A6
GO.0042221Response to chemical350.00529ABCG1, AKR1B1, ANKRD1, ANXA3, CAV1, CCL16, CDO1, CPEB3, CTGF, CTPS1, CUX2, CXCL5, CYP1A2, CYP2A7, DHCR24, FSTL3, GLYAT, GSTA1, GSTA3, HMGCS1, HSD17B2, KLF4, KRT19, MAT1A, MATN2, ME1, MRC1, MT1M, MYL9, NTN4, PELI1, SLC23A1, SLC47A1, STEAP2, UGT1A6
Deregulated by PB only in medium with EGF
GO.0048255mRNA stabilization40.00728DHX9, HNRNPC, SYNCRIP, THRAP3
Deregulated by PB in the presence and absence of EGF
GO.0006805Xenobiotic metabolic process131.5e−13CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4A11, SULT2A1, UGT1A1, UGT1A8
GO.0071466Cellular response to xenobiotic stimulus131.5e−13CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4A11, SULT2A1, UGT1A1, UGT1A8
GO.0017144Drug metabolic process99.51e−13CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A5, UGT1A1, UGT1A8
GO.0042737Drug catabolic process78.5e−11CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A5
GO.0019373Epoxygenase P450 pathway64.24e−09CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP4A11
GO.0042738Exogenous drug catabolic process67.24e−09CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4
GO.0032787Monocarboxylic acid metabolic process139.67e−09AKR1D1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP4A11, FASN, PDK4, POR, SULT2A1, UGT1A1, UGT1A8
GO.0044281Small molecule metabolic process221.24e−08ABCB1, AKR1D1, ALAS1, CYB5A, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4A11, DIO1, FASN, PDK4, POR, PRODH2, SULT2A1, UGT1A1, UGT1A8
GO.0019752Carboxylic acid metabolic process152.28e−08AKR1D1, CYB5A, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP4A11, FASN, PDK4, POR, PRODH2, SULT2A1, UGT1A1, UGT1A8
GO.0008202Steroid metabolic process104.36e−08AKR1D1, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP3A4, CYP3A5, SULT2A1, UGT1A1, UGT1A8