TABLE 3

CL_int of selected substrates in rat hepatocytes in static and shaken incubations

Data represent mean ± S.D. (n ≥ 3).

Substrate	CL_int		Average Fold Increase in CL_int
Substrate	Static	Shaken	Average Fold Increase in CL_int
	μl/min per 10⁶ cells
Chlorpromazine	366 ± 40.1	1940 ± 509^**	5.4
Dextromethorphan	168 ± 6.21	920 ± 222^**	5.5
Diclofenac	59.9 ± 5.78	192 ± 16.5^***	3.2
Midazolam	118 ± 27.9	303 ± 42.4^****	2.8
Metoprolol	38.3 ± 11.7	129 ± 39.4^**	3.4
Naloxone	238 ± 104	1110 ± 145^**	5.5
Propafenone	487 ± 81.0	2160 ± 312^***	4.4
Propranolol	520 ± 136	1210 ± 419^*	2.8
Saquinavir	138 ± 73.5	288 ± 143^**	2.8
Tolbutamide	0.191 ± 0.104	0.123 ± 0.108	0.6
Triazolam	73.2 ± 10.2	387 ± 227	5.2
Verapamil	188 ± 22.4	755 ± 68.8^***	4.0