Substrate | CLint | Average Fold Increase in CLint | |
---|---|---|---|
Static | Shaken | ||
μl/min per 106 cells | |||
Chlorpromazine | 366 ± 40.1 | 1940 ± 509** | 5.4 |
Dextromethorphan | 168 ± 6.21 | 920 ± 222** | 5.5 |
Diclofenac | 59.9 ± 5.78 | 192 ± 16.5*** | 3.2 |
Midazolam | 118 ± 27.9 | 303 ± 42.4**** | 2.8 |
Metoprolol | 38.3 ± 11.7 | 129 ± 39.4** | 3.4 |
Naloxone | 238 ± 104 | 1110 ± 145** | 5.5 |
Propafenone | 487 ± 81.0 | 2160 ± 312*** | 4.4 |
Propranolol | 520 ± 136 | 1210 ± 419* | 2.8 |
Saquinavir | 138 ± 73.5 | 288 ± 143** | 2.8 |
Tolbutamide | 0.191 ± 0.104 | 0.123 ± 0.108 | 0.6 |
Triazolam | 73.2 ± 10.2 | 387 ± 227 | 5.2 |
Verapamil | 188 ± 22.4 | 755 ± 68.8*** | 4.0 |