TABLE 6

Total clearance (CLT/F) of BMS-823778 after the last dose in Japanese subjects by predicted CYP2C19 phenotype and treatment group

Dose LevelCLT/F (ml/min) Mean [n] (CV)
CYP2C19 EM*CYP2C19 IM**CYP2C19 PM
2 mg (n = 6)55.51 [2] (10)37.85 [3] (31)12.50 [1]
12 mg (n = 6)58.47 [2] (15)33.13 [2] (24)16.68 [2] (29)
25 mg (n = 5)38.61 [2] (18)26.14 [2] (15)13.94 [1]

  • n, number of subjects with evaluable PK data; NA, not applicable.

  • ↵* P = 0.003 when CLT/F values of EMs across dose groups were compared with these of IMs; P < 0.001 when CLT/F values of EMs were compared with these of PMs.

  • ↵** P < 0.001 when CLT/F values of IMs were compared with those of PMs.