TABLE 5

Summary statistics for BMS-823778 PK parameters from the Japanese study by treatment group and study day

PK parameters were estimated using a noncompartment method.

Treatment GroupStudy DayCmax (ng/ml) Mean [n] (CV)Tmax (h) Median [n] (min-max)AUC (TAU) (ng.h/ml) Mean [n] (CV)CLT/F (ml/min) Mean [n] (CV)T-Half (h) Mean [n] (S.D.)
2 mg12.98 [6] (42)3.25 [6] (2.0–6.0)44.6 [6] (42)NANA
1457.4 [6] (58)1.75 [6] (1.0–3.0)944 [6] (72)35.3 [6] (44)81.8 [6] (68.8)
12 mg1108 [6] (17)1.75 [6] (1.0–3.0)1521 [6] (18)NANA
14375 [6] (49)1.50 [6] (1.0–3.0)6348 [6] (61)31.5 [6] (54)64.6 [6] (39.2)
25 mg1272 [6] (16)1.75 [6] (1.0–2.5)3593 [6] (19)NANA
14931 [6] (46)1.50 [6] (0.5–2.0)15,276 [6] (43)27.3 [6] (34)67.5 [6] (33.2)
  • CV, percent coefficient of variation; n, number of subjects with evaluable PK data; NA, not applicable.