Total clearance (CLT/F) of BMS-823778 after the last dose in Chinese subjects by predicted CYP2C19 phenotype and treatment group
| Dose Level | CLT/F (ml/min) Mean [n] (CV) | ||
|---|---|---|---|
| CYP2C19 EM* | CYP2C19 IM | CYP2C19 PM | |
| 2 mg (n = 14) | 56.7 [5] (45) | 28.1 [9] (22) | NA |
| 15 mg (n = 12) | 45.2 [3] (19) | 31.5 [8] (16) | 13.9 [1] |
n, number of subjects with evaluable PK data; NA, not applicable.
↵* P = 0.004 when CLT/F values of EM subjects in both dose groups were compared with IM subjects.