TABLE 3

Summary statistics of BMS-823778 PK parameters in healthy Chinese subjects after a single (day 1) or multiple daily doses (day 17) of BMS-823778 at 2 or 15 mg

PK parameters were estimated with a noncompartment method. AUC(INF), half-time, and CLT/F were excluded from the summary if AUC extrapolated >20%.

Treatment GroupStudy DayCmax (ng/ml) Mean [n] (CV)Tmax (h) Median [n] (Min-Max)AUC(TAU) (ng⋅h/ml) Mean [n] (CV)AUC(INF) (ng⋅h/ml) Mean [n] (CV)CLT/F (ml/min) Mean [n] (CV)Half-Time (h) Mean [n] (S.D.)
2 mg13.66 [15] (37)3.00 [15] (1.00, 24.00)201 [15] (35)NANANA
1757.2 [14] (33)2.00 [14] (0.50, 4.00)965 [14] (40)NA38.3 [14] (45)NA
15 mg1157 [14] (19)2.00 [14] (0.50, 3.00)4978 [14] (26)4951 [8] (20)50.5 [8] (32)30.1 [8] (4.18)
17463 [12] (34)1.50 [12] (1.00, 3.00)7827 [12] (41)NA33.5 [12] (28)NA
  • CV, percent coefficient of variation; n, number of subjects with evaluable PK data; NA, not applicable.