TABLE 1 

Reported impact of P. falciparum infection on drug pharmacokinetics in humans

DrugFindingsReference
QuinineIncreased plasma levels of quinine in five subjects with an experimentally induced infection.Trenholme et al. (1976)
QuinineIncreased serum quinine concentrations and lower CL in children with uncomplicated malaria.Sabchareon et al. (1982)
QuinineDecreased quinine CL in uncomplicated malaria, larger effect in cerebral malaria.White et al. (1982)
QuinineNo change in quinine FF in uncomplicated malaria; 25% decrease in cerebral malaria.Silamut et al. (1985)
QuinineLower FF of quinine in malaria patients, inversely correlated with α1-acid glycoprotein in the plasma.Mansor et al. (1991)
QuinineDecreased CL and increased plasma levels in uncomplicated malaria; decreased quinine FF.Supanaranond et al. (1991)
CaffeineDecreased caffeine CL, dependent on severity of infection.Wilairatana et al. (1994)
QuinineReduced CL, Vd, and liver blood flow in uncomplicated malaria.Pukrittayakamee et al. (1997)
QuinineIncreased quinine plasma levels and AUC in uncomplicated malaria.Babalola et al. (1998)
CaffeineNo effect on half-life, AUC, or CL in uncomplicated malaria; decreased paraxanthine to caffeine ratio.Akinyinka et al. (2000a)
CaffeineIn five children with malaria, decreased oral caffeine CL and increased and half-life.Akinyinka et al. (2000b)
QuinineIncreased quinine exposure in pregnant women with uncomplicated malaria.Kloprogge et al. (2014)
  • CL, clearance; FF, free fraction; Vd, volume of distribution.