Plasma pharmacokinetic parameters after treatment with 10 mg/kg TOL in CYP2C11-null rats and WT rats
All values are shown as the mean ± S.D., n = 6. *P < 0.05; **P < 0.01 compared with that of males in the same strain.
| Parameter | Male | Female | ||
|---|---|---|---|---|
| WT | Null | WT | Null | |
| AUC0-t (μg/ml per hour) | 648.62 ± 122.41 | 682.17 ± 97.42 | 1005.71 ± 54.53* | 1037.04 ± 218.00* |
| AUC0-∞ (μg/ml per hour)a | 675.66 ± 123.95 | 706.06 ± 93.97 | 1267.84 ± 99.70* | 1170.57 ± 271.00* |
| Cmax (μg/ml)a | 49.67 ± 10.07 | 56.65 ± 10.98 | 68.97 ± 9.41* | 82.85 ± 13.27* |
| Tmax (h)a | 4.08 ± 2.38 | 2.08 ± 1.50 | 1.75 ± 0.76 | 1.17 ± 0.41* |
| Vd/F (ml/kg) | 143.42 ± 34.52 | 131.94 ± 15.10 | 182.51 ± 38.97 | 147.35 ± 21.68 |
| Cl/F (ml/h per kilogram) | 15.24 ± 2.93 | 14.38 ± 1.98 | 7.93 ± 0.68** | 8.97 ± 2.25* |
AUC0-∞, area under the curve; AUC0-t, area under the blood concentration-time curve; CL/F, apparent oral clearance; Cmax, peak concentration; Tmax, time to reach Cmax; Vd/F, Apparent Volume of Distribution.