Summary of pharmacokinetic parameters (geometric mean, confidence interval 95%) for M1 and M8
| Analyte | Tmaxa | Cmax | AUClast | AUC∞ | t1/2 | CLr0–96 h |
|---|---|---|---|---|---|---|
| h | ng/ml | ng·h/ml | ng·h/ml | h | ml/min | |
| M1 (N = 8) | 0.5 (0.50–0.75) | 189 (112–320) | 287 (182–452) | 290 (185–455) | 12.9 (10.2–16.4) | 224 (182–276) |
| M1-to-verinurad ratio | — | 0.786 (0.606–1.02) | 1.01 (0.769–1.34) | 0.997 (0.761–1.31) | — | — |
| M1-to-total radioactivity ratio | — | 0.550 (0.428–0.705) | 0.340 (0.252–0.459) | 0.321 (0.238–0.432) | — | — |
| M8 (N = 8) | 0.75 (0.50–0.75) | 120 (102–142) | 273 (227–329) | 283 (235–342) | 18.1 (12.4–26.5) | 338 (286–399) |
| M8-to-verinurad ratio | — | 0.485 (0.381–0.617) | 0.936 (0.769–1.14) | 0.943 (0.777–1.14) | — | — |
| M8-to-total radioactivity ratio | — | 0.350 (0.282–0.433) | 0.324 (0.290–0.361) | 0.313 (0.279–0.351) | — | — |
AUC∞, area under the plasma concentration-time curve from zero to infinity; (t1/2, half-life;
↵a Tmax is expressed as median (range).