TABLE 1

Pharmacokinetic parameters of rosuvastatin A. Fixed parameters

Drug ParametersValuesReferences
Kpa0.0870Rodgers and Rowland. (2006)
Kpm0.144Rodgers and Rowland. (2006)
Kps0.439Rodgers and Rowland. (2006)
CLrLiters/h19.7Martin et al. (2003a)
CLint,metLiters/h1.59a
fb0.174Watanabe et al. (2010)
fh0.179b
βc0.2/0.31/0.5dFixed to three different values
γc0.25e
Dosepoµg40,000Martin et al. (2003a)
Doseivµg/h2,000Martin et al. (2003a)
FaFg0.429Martin et al. (2003a), Kato et al. (2003), Watanabe et al. (2010)