Activities of uptake transporters in SCHs and hepatocytes in suspension
| Substrate | Accumulation (pmol/min/mg protein or 106 cells) or Uptake Clearance (µl/min/mg protein) | References | |
|---|---|---|---|
| SCHs | Suspended Hepatocytes | ||
| CCK-8 (human) | 1.06 µl/min/mg protein | 2.44 µl/min/mg protein | Kotani et al. (2011) |
| Digoxin (human) | 3.8 ± 1.7 pmol/min per 106 cells | 5.2 ± 2.6 pmol/min per 106 cells | De Bruyn et al. (2011) |
| Estrone-3-sulfate (human) | 30.3 ± 13.0 pmol/min per 106 cells | 99.1 ± 67 pmol/min per 106 cells | De Bruyn et al. (2011) |
| 1-Methyl-4-phenylpyridinium (MPP+) (rat) | ∼17 pmol/min/mg protein | 91 pmol/min/mg protein | Jacobsen et al. (2011) |
| Pravastatin (human) | 2.95 µl/min/mg protein | 2.17 µl/min/mg protein | Kotani et al. (2011) |
| Rosuvastatin (human) | 9.48 µl/min/mg protein | 9.50 µl/min/mg protein | Kotani et al. (2011) |
| TCA (human) | 20.0 ± 7.9 pmol/min per 106 cells | 27.5 ± 15 pmol/min per 106 cells | De Bruyn et al. (2011) |
| TCA (rat) | 40.8 ± 5.7 pmol/min/mg protein at 10 µM | 52.8 ± 10.2 pmol/min/mg protein at 1 µM | Kemp et al. (2005) |