TABLE 1

Comparison of predicted and observed values for PK parameters for metformin

Simulation conditions are listed by rank order according to Σδ_all. δ is the absolute difference between one and the ratio of the predicted value of the parameter over the observed value, as defined by eq. 6 in the Materials and Methods section. Supplemental Table 39 provides actual parameter estimates as well as δ values.

	δ					Σδ_all	Σδ_R
	t_max	C_max	AUC	CL_R	A_e	Σδ_all	Σδ_R
Healthy
Sim healthy volunteers	0.191	0.007	0.172	0.162	0.062	0.595	0.224
Moderate RI
Sim GFR 30–60	0.328	0.536	0.674	2.15	0.249	3.94	2.40
OCT2 20%	0.040	0.347	0.374	0.192	0.056	1.01	0.248
OCT2 20% OCT2 R2	0.152	0.262	0.185	0.303	0.234	1.14	0.537
OCT2 20% OCT1 10%	0.248	0.150	0.038	0.191	0.524	1.15	0.715
OCT2 20% OCT1 10% OCT2 R2	0.536	0.000	0.470	0.303	0.361	1.67	0.664
OCT2 R2	0.136	0.403	0.477	0.631	0.048	1.69	0.679
OCT1 10% OCT2 R2	0.088	0.243	0.197	0.631	0.565	1.72	1.20
OCT1 10%	0.232	0.439	0.559	2.15	0.654	4.04	2.81
Severe RI
Sim GFR less than 30	0.282	0.463	0.563	1.10	0.036	2.45	1.14
OCT2 R2	0.012	0.310	0.278	0.018	0.186	0.806	0.204
OCT1 10% OCT2 R2	0.197	0.102	0.197	0.018	0.304	0.818	0.322
OCT2 20%	0.077	0.247	0.131	0.317	0.297	1.07	0.614
OCT2 20% OCT1 10%	0.347	0.008	0.608	0.318	0.248	1.53	0.566
OCT2 20% OCT2 R2	0.167	0.160	0.133	0.644	0.487	1.59	1.13
OCT1 10%	0.162	0.341	0.377	1.10	0.428	2.41	1.53
OCT2 20% OCT1 10% OCT2 R2	0.676	0.181	1.235	0.645	0.000	2.74	0.645