TABLE 1

B. Optimized parametersf

ParametersInitial ValuesRangeFitted Values
β = 0.2β = 0.31β = 0.5
ka (h−1)0.10.01–60.125 ± 0.0850.130 ± 0.0890.125 ± 0.083
kstomach (h−1)0.1Plus only0.413 ± 0.2970.346 ± 0.2100.291 ± 0.154
Rdifc0.0192b0.00502–0.0408b0.00502 ± 0.002460.00502 ± 0.003500.00502 ± 0.00685
kbile (h−1)1Plus only2.07 ± 2.562.17 ± 2.702.73 ± 4.47
CLint,all (Liters/h)c550gPlus only680 ± 34687 ± 38706 ± 48
WSSh10.812.616.9
AICi88.493.6103