mRNA expression levels of transporters in the mouse liver
Values are normalized by the expression of Gapdh and expressed as the mean ± S.D. (n = 4).
| Transporter Gene/Gapdh | Ratio (Slco1a4−/−/Wild-Type) | ||
|---|---|---|---|
| Wild Type | Slco1a4−/− | ||
| Slco1a1 | 0.144 ± 0.084 | 0.0982 ± 0.0675 | 0.68 |
| Slco1a4 | 2.87 ± 0.89 | 0.0595 ± 0.0386* | 0.021 |
| Slco1b2 | 1.29 ± 0.63 | 1.53 ± 1.21 | 1.2 |
| Slco2b1 | 1.04 ± 0.35 | 0.982 ± 0.722 | 0.95 |
| Abcc2 | 1.31 ± 0.15 | 1.03 ± 0.35 | 0.79 |
| Abcc3 | 0.298 ± 0.133 | 0.355 ± 0.362 | 1.2 |
| Abcb1a | 4.61 ± 1.68 | 6.24 ± 5.42 | 1.4 |
| Abcg2 | 0.920 ± 0.439 | 1.34 ± 1.46 | 1.5 |
| Abcb11 | 0.473 ± 0.292 | 0.722 ± 0.518 | 1.5 |
↵* P < 0.001.