TABLE 4

AUC and t1/2 values obtained by the moment analysis of the simulated blood concentration-time profiles

c.421C>A Genotypeβ = 0.2β = 0.31β = 0.5Reported Values
AUCt1/2 (h)AUCt1/2 (h)AUCt1/2 (h)AUCt1/2 (h)
(ng•h/ml)Ratio (vs. 421CC)(ng•h/ml)Ratio (vs.421CC)(ng•h/ml)Ratio (vs. 421CC)(ng•h/ml)Ratio (vs. 421CC)
c.421C>A polymorphism affects only intestinal BCRP (assumption 1)Keskitalo et al. (2009b)
CC42.6110.042.9110.443.1111.062.3114.0
CA54.91.2911.055.01.2811.355.21.2811.976.21.2213.6
AA96.72.2714.296.52.2514.596.22.2315.01522.4413.6
c.421C>A polymorphism affects only hepatic BCRP (assumption 2)Keskitalo et al. (2009b)
CC41.1111.840.7112.240.4113.662.3114.0
CA53.21.3011.353.31.3111.953.71.3313.276.21.2213.6
AA1092.649.911092.6710.41092.7011.81522.4413.6
c.421C>A polymorphism affects both of intestinal and hepatic BCRP (assumption 3)Keskitalo et al. (2009b)
CC40.8110.941.0111.141.3111.662.3114.0
CA54.11.3311.354.31.3211.654.51.3212.276.21.2213.6
AA1102.6912.51102.6712.91102.6613.71522.4413.6