TABLE 2

Comparison of the PBPK models used in the current study

Bottom-Up ApproachTop-Down Approach
Model 1Model 2Model 3Model 4Models 5
Scaling factors for hepatic transport and metabolismBiologic scaling factorsObtained by fitting
Incorporation of saturable hepatic uptakeYesYes
Incorporation of saturable hepatic metabolismYesYes
Fitted parametersIn vivo parameters of Vmax,uptake, Km,uptake, PSdif,inf, CLint,met, and VcIn vivo parameters of PSact, PSdif,inf, Vmax,met, Km,met, and VcIn vivo parameters of Vmax,uptake, Km,uptake, PSdif,inf, Vmax,met, Km,met, and Vc
  • Vc, distribution volume of the central compartment.