Parameters | Fitted values | ||
---|---|---|---|

β = 0.2 | β = 0.31 | β = 0.5 | |

CL_{int,bile} (Liters/h) | 15.4 ± 7.6^{k} | 18.3 ± 12.8^{k} | 26.6 ± 36.4^{k} |

PS_{act} (Liters/h) | 3383 ± 1658^{k} | 2205 ± 1538^{k} | 1405 ± 1918^{k} |

PS_{dif,eff} (Liters/h) | 67.9 ± 33.5^{k} | 44.3 ± 31.0^{k} | 28.2 ± 38.5^{k} |

PS_{dif,inf} (Liters/h) | 17.0 ± 8.4^{k} | 11.1 ± 7.7^{k} | 7.05 ± 9.64^{k} |

↵

^{a}In-house data obtained in metabolic study using human liver microsomes.↵

^{b}In-house data obtained in uptake study using suspended human hepatocytes.↵

^{c}Definition of these hybrid parameters were shown in*Materials and Methods*.↵

^{d}In-house data obtained in uptake study using sandwich-cultured human hepatocytes.↵

^{e}Determination of*γ*was shown in Supplemental Information.↵

^{f}Values are shown as the mean ± standard deviation.↵

^{g}Determined based on the clearance concept using reported intravenous data (Martin et al., 2003a).↵

^{h}WSS was calculated using eq. 13.↵

^{i}AIC was calculated using eq. 14.↵

^{j}All these parameters were mathematically calculated using parameters shown in Table 1A and 1B.↵

^{k}Standard deviation values were calculated by applying to the propagation of error assuming independent variables.