TABLE 2

Determination of the site of AO metabolism using high resolution mass spectrometry

Metabolite NameStructure[M+H]+Relevant Fragment Ions
m/zm/z
Lapatinib AO-M1Embedded Image597.13772474.10178, 365.05673, 323.05792
Lapatinib M3Embedded Image489.10093366.06452, 323.05869
INCB28060 AO-M1Embedded Image3429.14685398.10422, 251.09245, 142.06506
INCB28060 AO-M2Embedded Image429.14728398.10428, 384.12549, 251.09253, 158.06006
Duvelisib AO-M1Embedded Image433.11840282.06804, 152.05699
ML-347 AO-M1Embedded Image369.13516354.11123, 324.11349, 224.03090
SB-525334 AO-M1Embedded Image360.18157304.11942, 277.10864, 276.12395
LDN-193189 AO-M1Embedded Image423.19282380.15027, 304.15576, 280.15577, 237.07722
A77-01 AO-M1Embedded Image303.12359285.11343, 275.11767, 260.09494, 257.10725, 222.06608
Imatinib AO-M1Embedded Image510.26148410.16203, 290.12875, 264.11342, 217.13394, 189.13913, 147.05552
AMG900 AO-M1Embedded Image520.15406477.14780, 452.15268, 316.08917, 205.07149
Bafetinib AO-M1Embedded Image593.26139548.20245, 479.14459, 299.13730, 294.12360, 254.07922
Bafetinib AO-M2Embedded Image609.25641564.19720, 521.19165, 495.13937, 310.11719, 254.07880
Bafetinib AO-M3Embedded Image625.24979580.19275, 537.18671, 511.13425, 494.17987, 254.07925
CL-387785 AO-M1Embedded Image397.03054369.03494, 356.99857, 317.10362, 198.06644