TABLE 1

Half-lives of representative acyl glucuronide conjugates in aqueous buffer (pH 7.4) at 37°C

The data are adapted from Sawamura et al. (2010) and Zhang et al. (2011).

DrugChemical DescriptionHalf-life in pH 7.4 Buffer
hour
DiclofenacPhenylacetic acid0.7
IbufenacPhenylacetic acid0.9
IndomethacinIndole acetic acid1.6
TolmetinPyrrole acetic acid0.4
ZomepiracPyrrole acetic acid0.5
MontelukastCyclopropane acetic acid23.4
BenoxaprofenBenzoxazole propionic acid1.2
Ibuprofen2-Phenylpropionic acid3.0
Naproxen2-Napthylpropionic acid2.3
Gemfibrozil2,2-Dimethylvaleric acid63
Flufenamic acidAnthranilic acid8.1
FurosemideAnthranilic acid4.1
Meclofenamic acidAnthranilic acid28.1
Mefanamic acidAnthranilic acid16.8
ProbenicidPara-substituted Benzoic acid0.4
Repaglinide2-Ethoxybenzoic acid11.5
TelemisartanBiphenyl-2-carboxylic acid44.5
MuraglitazarPhenylmethylaminoacetic acid1.2
PeliglitazarPhenylethylaminoacetic acid10.1