Substrate | Cell Type | Km | Vmax | Vmax/Km |
---|---|---|---|---|
µM | pmol/min per milligram | µl/min per milligram | ||
E3S | HEK293-OATP1B1 | 0.52 ± 0.03 | 45.4 ± 0 | 87.7 |
CCK-8 | HEK293-OATP1B3 | 3.1 ± 0.7 | 55.1 ± 16.5 | 19.0 |
TCA | HEK293-NTCP | 14.9 | 1191 | 79.9 |
Pitavastatin | HEK293-OATP1B1 | 4.2 ± 0.1 | 187.2 ± 32.5 | 44.4 ± 6.7 |
HEK293-OATP1B3 | 2.2 ± 0.1 | 74.2 ± 37.8 | 32.6 ± 14.8 | |
HEK293-NTCP | 24.3 ± 3.1 | 866 ± 283 | 35.2 ± 7.1 |
Each experiment was done twice except the TCA uptake experiment in HEK293-NTCP, which was done once.