Optimized top five drug-dependent parameter sets of GEM/GEM-glu selected to minimize the weighted sum of squares (WSS) from the observed clinical data by Cluster Newton Method (CNM)
Parameters | Units | Initial Range | 1st | 2nd | 3rd | 4th | 5th | |
---|---|---|---|---|---|---|---|---|
GEM | Vcentral | L/kg | 0.075–0.75 | 0.077 | 0.075 | 0.077 | 0.089 | 0.076 |
ka | /h | 0.06–6 | 1.463 | 2.574 | 1.611 | 1.275 | 4.733 | |
ktransit | /h | 0.06–6 | 3.645 | 2.872 | 2.378 | 6.585 | 1.488 | |
fb*CLint,all | L/hr/kg | 0.0105–1.05 | 0.157 | 0.173 | 0.165 | 0.154 | 0.199 | |
1/fglu | 1.1–10 | 1.210 | 1.118 | 1.263 | 1.105 | 1.273 | ||
GEM-glu | Vcentral | L/kg | 0.075–0.75 | 0.076 | 0.076 | 0.087 | 0.150 | 0.088 |
ka | /h | 0.06–6 | 0.258 | 0.109 | 0.106 | 0.155 | 0.142 | |
Rdif | 0.0275–0.11 | 0.051 | 0.103 | 0.064 | 0.079 | 0.096 | ||
1/β | 1.1–10 | 5.727 | 2.119 | 6.318 | 14.039 | 2.779 | ||
fb*CLint,all | L/hr/kg | 0.0156–1.56 | 0.245 | 0.159 | 0.293 | 0.314 | 0.184 | |
kbile | /h | 0.06–6 | 0.205 | 0.209 | 2.235 | 0.095 | 3.807 | |
kdeconj | /h | 0.06–6 | 0.856 | 1.179 | 0.073 | 0.189 | 0.824 | |
kf | /h | 0.06–6 | 0.938 | 1.414 | 0.906 | 0.067 | 2.466 | |
WSS | 1.202 | 1.319 | 1.514 | 1.521 | 1.586 |