TABLE 2

Optimized top five drug-dependent parameter sets of GEM/GEM-glu selected to minimize the weighted sum of squares (WSS) from the observed clinical data by Cluster Newton Method (CNM)

	Parameters	Units	Initial Range	1st	2nd	3rd	4th	5th
GEM	V_central	L/kg	0.075–0.75	0.077	0.075	0.077	0.089	0.076
	k_a	/h	0.06–6	1.463	2.574	1.611	1.275	4.733
	k_transit	/h	0.06–6	3.645	2.872	2.378	6.585	1.488
	f_b*CL_int,all	L/hr/kg	0.0105–1.05	0.157	0.173	0.165	0.154	0.199
	1/f_glu		1.1–10	1.210	1.118	1.263	1.105	1.273
GEM-glu	V_central	L/kg	0.075–0.75	0.076	0.076	0.087	0.150	0.088
	k_a	/h	0.06–6	0.258	0.109	0.106	0.155	0.142
	R_dif		0.0275–0.11	0.051	0.103	0.064	0.079	0.096
	1/β		1.1–10	5.727	2.119	6.318	14.039	2.779
	f_b*CL_int,all	L/hr/kg	0.0156–1.56	0.245	0.159	0.293	0.314	0.184
	k_bile	/h	0.06–6	0.205	0.209	2.235	0.095	3.807
	k_deconj	/h	0.06–6	0.856	1.179	0.073	0.189	0.824
	k_f	/h	0.06–6	0.938	1.414	0.906	0.067	2.466
WSS				1.202	1.319	1.514	1.521	1.586