TABLE 3
Structural alerts for constituents in select natural products
| Constituent(s)/Natural Product | Structural Alert | Alert Substructure |
|---|---|---|
| Flavonoids, phenylpropanoids/Echinacea Glycyrrhizin, glycyrrhizinic acid/licorice | Catechols |  |
| Isoquinoline alkaloids/goldenseal Terpenoids/cinnamon Curcuminoids/turmeric | Masked catechol |   |
| Isoquinoline alkaloids/goldenseal Shizandrins/Schisandra spp. Gomisins/Schisandra spp. | Methylene dioxyphenyl |  |
| Cycloartenol/black cohosh | Subterminal olefin |  |
| Polyacetylenes/Echinacea | Terminal and subterminal acetylenes |   |
| Terpenoids/cinnamon Diallyl di- and trisulfides/garlic | Terminal olefin |  |
| Cinnamaldehyde/cinnamon | α,β-Unsaturated aldehyde |  |
| Curcuminoids/turmeric | α,β-Unsaturated ketone |  |