Comparison of Cmax and AUC(0–24h) of CPI and CPIII in healthy subjects (n = 14) following administration of diltiazem (240 mg) or itraconazole (200 mg)
Data are expressed as mean ± S.D.
| Treatment | CPI | CPIII | |||
|---|---|---|---|---|---|
| Cmax | AUC(0–24h) | Cmax | AUC(0–24h) | ||
| nM | nM*h | nM | nM*h | ||
| Diltiazem group (n = 14) | Diltiazem | 0.79 ± 0.21* | 15.91 ± 6.27 | 0.15 ± 0.04*** | 2.80 ± 1.01 |
| Basala | 0.70 ± 0.17 | 16.88 ± 3.78 | 0.12 ± 0.02 | 2.71 ± 0.58 | |
| Fold-change | 1.11 ± 0.10 | 1.00 ± 0.10 | 1.32 ± 0.22 | 1.17 ± 0.44 | |
| Itraconazole group (n = 14) | Itraconazole | 0.96 ± 0.23** | 19.42 ± 5.33 | 0.16 ± 0.03** | 2.95 ± 0.83 |
| Basala | 0.86 ± 0.23 | 20.69 ± 5.57 | 0.13 ± 0.03 | 3.23 ± 0.59 | |
| Fold-change | 1.12 ± 0.10 | 0.94 ± 0.10 | 1.17 ± 0.17 | 0.95 ± 0.13 | |
↵a Baseline control values of Cmax and AUC(0–24h) were calculated using predose levels.
* P < 0.05, **P < 0.01, ***P < 0.001, statistically significant difference compared with the control.