PBPK Model | Precipitant Drug | Groupa | Kib | Cmax | AUC | CmaxRc | AUCRc |
---|---|---|---|---|---|---|---|
μM | ng/ml | ng⋅h/ml | ratio | ratio | |||
ADAM | Itraconazole | Control | − | 114 (51) | 2578 (71) | − | − |
Test | − | 228 (46) | 21,108 (123) | 2.0 (1.9–2.1) | 8.5 (6.5–10) | ||
0.5 | 229 (46) | 21,159 (123) | 2.0 (1.9–2.1) | 8.5 (6.5–10) | |||
Verapamil | Control | − | 112 (49) | 2528 (70) | − | − | |
Test | − | 190 (50) | 11,269 (110) | 1.7 (1.6–1.8) | 4.5 (3.7–5.3) | ||
0.16 | 226 (49) | 13,015 (111) | 2.0 (1.9–2.2) | 5.1 (4.3–6.2) |