Methamphetamine, amphetamine, and p-OHMA tissue to plasma AUC0–480 ratios in Oct3+/+ and Oct3−/− mice
Data are presented as mean ± S.E. Statistical significance was determined between genotypes for each analyte in each tissue using a permutation test with multiple comparisons corrected using the Bonferroni method, as detailed in Materials and Methods.
| Tissue | Methamphetamine | Amphetamine | p-OHMA | |||
|---|---|---|---|---|---|---|
| Oct3+/+ | Oct3−/− | Oct3+/+ | Oct3−/− | Oct3+/+ | Oct3−/− | |
| Salivary glands | 4.8 ± 0.68 | 4.4 ± 0.48 | 3.9 ± 0.78 | 4.0 ± 0.89 | 9.4 ± 1.9 | 4.5 ± 0.89* |
| Muscle | 0.97 ± 0.25 | 1.2 ± 0.16 | 0.37 ± 0.078 | 0.63 ± 0.15 | 3.9 ± 1.1 | 0.91 ± 0.34 |
| Heart | 1.9 ± 0.29 | 2.3 ± 0.49 | 1.4 ± 0.22 | 1.7 ± 0.46 | 2.9 ± 0.75 | 2.4 ± 1.4 |
| Adipose | 0.44 ± 0.11 | 0.39 ± 0.075 | 0.24 ± 0.071 | 0.31 ± 0.13 | N.D. | N.D. |
| Liver | 4.3 ± 0.65 | 4.8 ± 0.71 | 4.1 ± 1.1 | 3.9 ± 0.91 | 17 ± 3.5 | 16 ± 3.7 |
| Kidney | 6.7 ± 0.87 | 8.3 ± 1.0 | 12 ± 2.4 | 16 ± 3.3 | 10 ± 3.3 | 6.6 ± 1.4 |
| Brain | 6.4 ± 1.8 | 5.3 ± 0.55 | 7.1 ± 2.5 | 5.3 ± 0.98 | 4.8 ± 0.86 | 1.8 ± 0.64 |
N.D., Not determined.
↵* P < 0.05.