Methamphetamine plasma pharmacokinetic parameters in Oct3+/+ and Oct3−/− mice
Data are presented as mean ± S.E. No statistically significant differences were determined between genotypes for each pharmacokinetic parameter using a permutation test with multiple comparisons corrected using the Bonferroni method, as detailed inMaterials and Methods.
Parameters
Oct3+/+
Oct3−/−
AUCinf (μM × min)
2600 ± 270
2200 ± 210
Terminal t1/2 (min)
35 ± 4.2
59 ± 5.2
Clearance (ml/min per kilogram)
26 ± 2.6
31 ± 3.0
Vss (l/kg)
1.3 ± 0.23
1.8 ± 0.26
t1/2, half-life; Vss, volume of distribution at steady state.