Methamphetamine plasma pharmacokinetic parameters in Oct3+/+ and Oct3−/− mice
Data are presented as mean ± S.E. No statistically significant differences were determined between genotypes for each pharmacokinetic parameter using a permutation test with multiple comparisons corrected using the Bonferroni method, as detailed in Materials and Methods.
| Parameters | Oct3+/+ | Oct3−/− |
|---|---|---|
| AUCinf (μM × min) | 2600 ± 270 | 2200 ± 210 |
| Terminal t1/2 (min) | 35 ± 4.2 | 59 ± 5.2 |
| Clearance (ml/min per kilogram) | 26 ± 2.6 | 31 ± 3.0 |
| Vss (l/kg) | 1.3 ± 0.23 | 1.8 ± 0.26 |
t1/2, half-life; Vss, volume of distribution at steady state.