TABLE 2

Methamphetamine, amphetamine, and p-OHMA tissue AUC_0–480 (μM × min) in Oct3^+/+ and Oct3^−/− mice

Data are presented as mean ± S.E. Statistical significance was determined between genotypes for each analyte in each tissue using a permutation test with multiple comparisons corrected using the Bonferroni method, as detailed in Materials and Methods.

Tissue	Methamphetamine		Amphetamine		p-OHMA
Tissue	Oct3^+/+	Oct3^−/−	Oct3^+/+	Oct3^−/−	Oct3^+/+	Oct3^−/−
Plasma	2600 ± 300	2200 ± 210	330 ± 44	250 ± 38	2.5 ± 0.42	2.6 ± 0.49
Salivary glands	12,000 ± 1100	9500 ± 510	1300 ± 200	1000 ± 160	24 ± 2.7	12 ± 0.85^**
Muscle	2500 ± 580	2600 ± 240	120 ± 21	160 ± 28	9.9 ± 2.4	2.4 ± 0.77^*
Heart	4900 ± 500	5100 ± 950	460 ± 44	420 ± 99	7.3 ± 1.5	6.4 ± 3.6
Adipose	1100 ± 260	851 ± 140	79 ± 21	78 ± 31	N.D.	N.D.
Liver	11,000 ± 1100	10,000 ± 1200	1400 ± 310	990 ± 180	42 ± 5.9	42 ± 5.7
Kidney	17,000 ± 1100	18,000 ± 1400	3900 ± 620	4000 ± 570	27 ± 7.1	17 ± 2.0
Brain	17,000 ± 4200	12,000 ± 560	2400 ± 790	1300 ± 140	12 ± 0.84	4.7 ± 1.4

N.D., Not determined.
↵* P < 0.05; **P < 0.01.