Cisplatin toxicity in ciPTEC in 2D cultures and recellularized scaffolds in this study in comparison with published in vitro data
| Condition | TC50 (μM) | Reference | |
|---|---|---|---|
| PrestoBlue assay | ciPTEC–OAT1 2D (24 h) | 108 ± 10 | |
| RS (24 h) | 12 ± 5 | ||
| Live/Dead assay | RS (24 h) | 11.4 ± 1.1 | |
| Literature | ciPTEC–OAT1 2D (72 h) | 32 ± 18 | Caetano-Pinto et al. (2017) |
| MDCK (24 h) | 18 ± 2 | Garbutcheon-Singh et al. (2013) | |
| HEK-293 (72 h) | 2.3 ± 0.3 | Shen et al. (2013) | |
| HEK-293–OCT2 (72 h) | 1.4 ± 0.2 | ||
| HEK-293–MATE1 (72 h) | 1.1 ± 0.1 | ||
| HEK-293–MATE2k (72 h) | 0.9 ± 0.1 |
HEK-293–MATE1, human embryonic kidney cells 293 overexpressing MATE1; HEK-293–MATE2, human embryonic kidney cells 293 overexpressing MATE2; HEK-293–OCT2, human embryonic kidney 293 cells overexpressing OCT-2s; MDCK, Madin-Darby canine kidney.