M1a % | M1b % | M2a % | M2b % | M3a % | M3b % | |
---|---|---|---|---|---|---|
Plasma in vivo | ||||||
Humans | 79.3 | 20.7 | 94.6 | 5.4 | 99.1 | 0.9 |
Dogs | 91.2 | 8.8 | 89.1 | 10.9 | 90.7 | 9.3 |
Rats | na | na | na | na | na | na |
Total mass balance in vivo | ||||||
Humans | 86.0 | 14.0 | 93.6 | 6.4 | 97.3 | 2.7 |
Dogs | 87.5 | 12.5 | 83.3 | 16.7 | 83.8 | 16.2 |
Rats | 87.7 | 12.3 | 93.9 | 6.1 | 87.5 | 12.5 |
Liver microsomes | ||||||
Humans | 94.6 | 5.4 | 96.2 | 3.8 | — | — |
Dogs | 92.5 | 7.5 | 91.9 | 8.1 | — | — |
Rats | 95.5 | 4.5 | 96.8 | 3.2 | 93.7 | 6.3 |
Recombinant enzymes | ||||||
CYP2C8 | 70.7 | 29.3 | — | — | — | — |
CYP3A4 | 95.7 | 4.3 | 97.8 | 2.2 | — | — |
na, Not applicable.