TABLE 2

 Pharmacokinetic parameters for mice after administration of coumarin (i.p.)

Groupt1/2TmaxCmaxAUC0–t
minminμg/ml(μg/ml)*min
Coumarin
 ZT27.44 ± 0.9853.15 ± 0.1748.14 ± 6.15
 ZT146.44 ± 0.5254.19 ± 0.9256.34 ± 7.53
7-Hydroxycoumarin
 ZT211.670.0127 ± 0.00230.33 ± 0.01
 ZT146.670.0093 ± 0.00060.18 ± 0.01*
  • AUC0–t, area under the plasma concentration-time curve.

  • * P < 0.05 vs. ZT2 group.