TABLE 2

A list of transporters commonly associated with the transport of drugs and xenobiotics in the kidney proximal tubule

Common Name (Symbol)Gene Family-Derived NameLocalization
Organic cation transporter 2 (OCT2)SLC22A2Basolateral
Organic anion transporter 1 (OAT1)SLC22A6Basolateral
Organic anion transporter 3 (OAT3)SLC22A8Basolateral
Organic anion transporter 4 (OAT4)SLC22A11Apical
Urate anion exchanger 1 (URAT1)SLC22A12Apical
Multidrug and toxin extrusion protein 1 (MATE1)SLC47A1Apical
Multidrug and toxin extrusion protein 2K (MATE2K)SLC47A2Apical
Oligoeptide transporter 1 (PEPT1)SLC15A1Apical
Oligoeptide transporter 2 (PEPT2)SLC15A2Apical
Multidrug resistance protein 1 (P-gp)ABCB1Apical
Breast cancer resistance protein (BCRP)ABCG2Apical
Multidrug resistance associated rrotein 2 (MRP2)ABCC2Apical
Multidrug resistance associated protein 4 (MRP4)ABCC4Apical