TABLE 1

 Drug transporters recommended by regulatory agencies and the ITC for evaluation in drug development including prospective and retrospective studies and key organ expression

TransporterGeneLiverKidneyIntestineBBB
Established
 OAT1SLC22A6X
 OAT3SLC22A8X
 OCT2SLC22A2X
 P-gpABCB1XXXX
 BCRPABCG2XXXX
 OATP1B1SLCO1B1X
 OATP1B3SLCO1B3X
 MATE1SLC47A1XX
 MATE2SLC47A2X
Emerging
 OATP2B1SLCO2B1XX
 BSEPABCB11X
 MRP2ABCC2XXX
 MRP3ABCC3XXX
 MRP4ABCC4XX
 OCT1SLC22A1X
  • Established transporters are required for evaluation by regulatory agencies (e.g., the U.S. Food Drug Administration, the European Medicines Agency, and the Japanese Pharmaceuticals and Medical Devices Agency). Emerging transporters are recognized as potentially relevant, although their clinical impact is not yet fully understood and established.