Overview of metabolic reactions of drugs observed in fermentation screening platform
| Drug | Metabolic Reaction Observed In Vitro | Metabolic Reaction Observed In Vivo (Species) |
|---|---|---|
| Sulfasalazine | Azo reduction | Peppercorn and Goldman (1972) (rat and human) |
| Sulfinpyrazone | Sulfoxide reduction (deoxygenation) | Strong et al. (1987) (rabbit and human) |
| Sulindac | Sulfoxide reduction (deoxygenation) | Strong et al. (1987) (rabbit and human) |
| Nizatidine | Nitrogen oxide reduction (deoxygenation) | Basit et al. (2002) (human) |
| Risperidone | Isoxazole scission due to N-O bond reduction and subsequent hydrolysis of imine intermediate | Mannens et al. (1993), Meuldermans et al. (1994) (rat, dog, and human) |