TABLE 2

Effects of varying k_a on estimates of T_max and C_max from simulated blood data, which contained 5% assay error

Values assigned were: α, β, and k₂₁ = 0.8, 0.2, and 0.5 h⁻¹, respectively.

k_a (h⁻¹)	True Value	Two-Compartment Model			Observed Values (FDA method)
k_a (h⁻¹)	T_max,true (h)	T_max,2comp (h)	%Bias^{^a}	RSD^{^b}	T_max,obs (h)	%Bias	RSD
3	0.743	0.744	0.181%	5.67%	0.782	5.28%	20.4%
2	0.972	0.971	−0.0257%	4.62%	0.947	−2.58%	19.9%
1	1.51	1.52	0.310%	3.85%	1.62	7.36%	19.1%
0.1	5.77	5.75	−0.351%	5.08%	6.01	4.01%	21.1%
0.05	8.07	7.97	−1.17%	5.78%	7.93	−1.69%	23.0%

k_a (h⁻¹)	C_max,true (μg/ml)	C_max,2comp (μg/ml)	%Bias	RSD	C_max,obs (μg/ml)	%Bias	RSD
3	70.7	70.9	0.222%	2.54%	72.1	2.04%	3.76%
2	64.2	64.1	−0.0779%	2.49%	65.3	1.74%	3.98%
1	51.9	51.8	−0.0675%	2.19%	52.8	1.76%	3.90%
0.1	16.3	16.3	0.338%	2.62%	16.6	2.00%	3.76%
0.05	10.0	10.1	0.169%	2.69%	10.2	2.09%	3.81%