TABLE 2

A summary of the non-P450 pathway-selective substrates and their respective metabolites quantified in CHIM

DME PathwaySubstrateSubstrate ConcentrationMetabolites Quantified
┬ÁM
ECOD7-Ethoxycoumarin1007-HC, 7-HC-sulfate, 7-HC-glucuronide
UGT7-HC1007- HC-glucuronide
SULT7-HC1007-HC-sulfate
FMOBenzydamine HCl250Benzydamine-N-oxide
MAOKynuramine HBr1604-Hydroxyquinoline
AOCarbazeran204-Hydroxycabazeran
NAT14-Aminobenzoic acid200N-Acetyl-p-aminobenzoic acid
NAT2Sulfamethazine100N-Acetyl-sulfamethazine
CES2Irinotecan50SN38
  • DME, Drug Metabolizing Enzymes; HBr, hydrobromide; HC, hydroxycoumarin; HCl, hydrochloride; SN38, 7-ethyl-10-hydroxycambdothecin.