TABLE 2

Comparison of MMHHs in the metabolism of acetaminophen at the noncytotoxic concentration of 10 mM

Mean and S.D. of triplicate samples are shown.

Incubation TimeTotal Metabolite Formation in MMHHs (nmoles per Million Hepatocytes)
APAP GlucuronideAPAP SulfateAPAP Glutathione
MeanS.D.MeanS.D.MeanS.D.
min
303.620.290.920.191.780.10
608.400.411.950.214.120.17
12042.661.463.950.3217.560.70
24075.320.684.820.2818.741.01