TABLE 5

P450 isoform-specific activities of CHIM isolated from the duodenum, jejunum, and ileum of donors 1, 2, and 4 and from the small intestine (from the duodenum to ileum) of donor 3

IsoformActivity
Donor 1Donor 2Donor 3Donor 4
DuodenumJejunumIleumDuodenumJejunumIleumCombinedDuodenumJejunumIleum
pmol/min per milligram protein
CYP1A11.461.233.271.580.891.182.100.650.190.14
CYP1A25.104.998.6012.773.540.912.822.065.952.88
CYP2A60.010.010.010.020.010.03BQLBQLBQLBQL
CYP2B60.971.111.841.260.420.361.300.601.010.57
CYP2C80.080.130.160.080.030.030.090.080.130.18
CYP2C93.5113.6014.932.671.860.240.290.260.380.43
CYP2C194.793.391.4312.851.71BQL0.180.200.950.83
CYP2D60.180.16BQL0.280.05BQLBQL0.02BQL0.04
CYP2E10.360.370.660.030.570.660.31BQLBQL0.05
CYP3A4/5-111.2718.608.402.514.02BQL0.670.371.891.54
CYP3A4/5-2146.77195.8399.43116.3038.142.2812.4110.7825.4325.54
CYP2J23.492.715.732.412.382.144.181.713.002.55
  • BQL, below limits of quantification.