Comparison of CCHHs and MMHHs in acetaminophen metabolism at the lesser cytotoxic concentration of 100 mM and the cytotoxic concentration of 200 mM
Mean and S.D. of triplicate samples are shown.
| Substrate Concentration (µM) | Marker Metabolite | Total Metabolite Formation (pmol per Million Hepatocytes) | |||
|---|---|---|---|---|---|
| CCHH | MMHH | ||||
| Average | S.D. | Average | S.D. | ||
| mM | |||||
| 100 | Acetaminophen Glutathione | 206.50 | 3.91 | 856.72 | 71.28 |
| 200 | Acetaminophen Glutathione | 99.81 | 7.49 | 676.70 | 54.43 |
| 100 | Acetaminophen Glucuronide | 572.55 | 27.12 | 1298.77 | 64.29 |
| 200 | Acetaminophen Glucuronide | 170.28 | 16.38 | 1361.84 | 83.36 |
| 100 | Acetaminophen Sulfate | 105.55 | 3.36 | 150.22 | 6.68 |
| 200 | Acetaminophen Sulfate | 52.58 | 1.40 | 156.36 | 11.86 |