Drug | Administration | Objective Function | Supplemental Data | Reference (PubMed ID) |
---|---|---|---|---|
Clarithromycina | ||||
Fluconazole | Single intravenous/oral | AUCinf | Table 1, Fig. 1 | 2540363 |
Fluoxetine | Single/multiple oral | AUCinf | Tables 2.1, 2.2; Figs. 2.1, 2.2 | 1544284 |
Fluvoxamine | Single oral | AUCinf | Table 3, Fig. 3 | 8499580 |
Itraconazole | Multiple oral | AUCinf | Table 4, Fig. 4 | 2848442 |
Paroxetinea | ||||
Quinidine | Single oral | AUCinf | Table 5, Fig. 5 | 7693389 |
Voriconazole | Multiple oral | AUCinf | Table 6, Fig. 6 | 16291712 |
AUC, area under the plasma concentration–time curve; AUCinf, AUC from time zero to infinity.
↵a Plasma concentration–time profiles were not considered in the analyses of DDI and were not analyzed with PBPK models because the inhibition of CYP enzymes involved mechanism-based inhibition.