TABLE 8

Non-P450 drug-metabolizing enzyme activities of CHIM isolated from the duodenum, jejunum, and ileum of donors 1, 2, and 4 and from the entire small intestine (from duodenum to ileum) of donor 3

Metabolic PathwayActivity
Donor 1Donor 2Donor 3Donor 4
DuodenumJejunumIleumDuodenumJejunumIleumCombinedDuodenumJejunumIleum
pmol/min per milligram protein
ECOD0.745.751.560.150.080.050.920.730.531.50
UGT6.888.6022.1914.462.56BQL0.020.360.700.32
SULT0.070.150.076.881.24BQL0.012.642.330.66
FMO7.066.028.878.595.413.559.259.1210.406.53
MAO303.64480.99740.74790.12207.3018.0681.59213.17448.71147.49
AO0.030.020.050.01BQLBQL0.04BQLBQL0.02
NAT15.4510.8736.6194.2015.843.4615.161.921.821.14
NAT23.383.995.603.301.320.761.981.311.811.62
CES21.631.222.560.830.600.502.410.961.421.45
  • BQL, below limits of quantification.