Metabolic Pathway | Activity | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Donor 1 | Donor 2 | Donor 3 | Donor 4 | |||||||
Duodenum | Jejunum | Ileum | Duodenum | Jejunum | Ileum | Combined | Duodenum | Jejunum | Ileum | |
pmol/min per milligram protein | ||||||||||
ECOD | 0.74 | 5.75 | 1.56 | 0.15 | 0.08 | 0.05 | 0.92 | 0.73 | 0.53 | 1.50 |
UGT | 6.88 | 8.60 | 22.19 | 14.46 | 2.56 | BQL | 0.02 | 0.36 | 0.70 | 0.32 |
SULT | 0.07 | 0.15 | 0.07 | 6.88 | 1.24 | BQL | 0.01 | 2.64 | 2.33 | 0.66 |
FMO | 7.06 | 6.02 | 8.87 | 8.59 | 5.41 | 3.55 | 9.25 | 9.12 | 10.40 | 6.53 |
MAO | 303.64 | 480.99 | 740.74 | 790.12 | 207.30 | 18.06 | 81.59 | 213.17 | 448.71 | 147.49 |
AO | 0.03 | 0.02 | 0.05 | 0.01 | BQL | BQL | 0.04 | BQL | BQL | 0.02 |
NAT1 | 5.45 | 10.87 | 36.61 | 94.20 | 15.84 | 3.46 | 15.16 | 1.92 | 1.82 | 1.14 |
NAT2 | 3.38 | 3.99 | 5.60 | 3.30 | 1.32 | 0.76 | 1.98 | 1.31 | 1.81 | 1.62 |
CES2 | 1.63 | 1.22 | 2.56 | 0.83 | 0.60 | 0.50 | 2.41 | 0.96 | 1.42 | 1.45 |
BQL, below limits of quantification.