Inhibition of quinoline analogs metabolism by various molybdenum hydroxylase inhibitors in liver cytosol fractions
| Species | Percentage of Control Activity | ||||||
|---|---|---|---|---|---|---|---|
| Human | Human | Human | Human | Human | Mouse | ||
| % | |||||||
| Inhibitor (concentration) | Analog | 63 | 53 | 51 | 11 | 71 | 11 |
| Menadione (50 µM) | 20 | 9 | 22 | 49 | 9 | 7 | |
| Raloxifene (20 µM) | 23 | 2 | 13 | 65 | 2 | 14 | |
| Allopurinol (50 µM) | 118 | 83 | 92 | 110 | 86 | 98 | |