Kinetic study conditions for triazolopyridine compounds in liver cytosol incubation from different species
| Species | Test Compounds | |||||
|---|---|---|---|---|---|---|
| 71 | 11 | 51 | 53 | 63 | ||
| Compound concentration (μM) | 0.23–30 | 0.47–60 | 0.23–30 | 0.23–30 | 0.47–60 | |
| Liver cytosol protein concentration (mg/ml) | Monkey | 0.1 | 0.2 | 0.1 | 0.1 | 1.0 |
| Mouse | 0.5 | 0.5 | 0.5 | 0.5 | 1.0 | |
| Human | 0.5 | 0.5 | 0.5 | 0.5 | 1.0 | |
| Rat | 0.5 | 0.5 | 0.5 | 0.5 | 1.0 | |