TABLE 4

Potential categorization of ABCG2 SNPs

GroupExample SNPCell Surface ExpressionDrug Transport
1aWild typeAs wild typeAs wild type
1bS248P, P269S, F431LAs wild typeImpaired
2aV12M, Q126X, Q141K, T153M, F208S, S441N, F489L, -15622 C>T, 1143 C>TReducedImpaired
2bI206LReducedElevated
3aN590Y, D620NIncreasedImpaired
3b−15994 C>TIncreasedElevated